(coughs)
(laughs)
- This is what happens when I don't sleep.
We've all heard that eight hours of sleep per night rule
but this report isn't going to write itself
and besides, a little sleep deprivation never hurt anybody.
Wha-ho! Whoa.
Okay, so wow!
Okay, that is not good.
I'm Shannon and I'm a PhD neuroscience candidate
and this is your brain on sleep deprivation.
(uptempo rock music)
Though I may stay up late to finish a big paper
do I actually have the mental ability
to think coherently while sleep deprived?
(laughs)
Science suggests that sleep deprivation majorly reduces
cognitive performance, especially memory, being alert,
paying attention, performing tasks, and memory.
After sleep depriva-- how should I say it?
How do humans say this line?
During sleep deprivation, FMRI studies show periods
of decreased activation in the medial frontal cortex,
visual sensory cortex, and thalamic regions
while trying to perform a task.
My inability to finish this paper may also be due
to the phenomenon known as microsleeps.
These are involuntary, momentary, sleep-like states
of unconsciousness which occur
for a few seconds while sleep deprived
You may note it as...
You may (laughs)
You may know it as nodding off when you're trying
to stay awake and it's a regular occurrence
for 38% of adults, the more sleep deprived you are,
the longer these microsleeps may last until you are
involuntarily pushed into a full-on sleep.
I don't know.
It sounds kind of nice right now.
When I'm tired but I decide that it's more important
to stay awake then to fall asleep
I'm actively preventing my brain from recharging.
The brain carefully coordinates sleeping and waking
in multiple regions led by the ventrolateral preoptic
nucleus or the VLPO, for short.
It's a group of neurons located in the hypothalamus.
This cluster of neurons is inhibitory and projected
different nuclei of the hypothalamus, the brain stem,
and the thalamus a.k.a the big players in your awake system.
(laughs)
I don't know...
You can think of the VLPO as kind of like the off switch
of your brain and right now, I'm in an intense battle
with my body to keep that switch from flipping
into sleep mode.
And while my sleep deprived brain can't pay attention
to my paper, I'm also having a hard time remembering
what exactly I'm supposed to be writing about.
Sleep?
Sleep deprivation seriously affects short term memory
and your ability to encode and retain episodic memories.
In fact, just a single night of sleep deprivation
has been shown to result in lower activation of your
hippocampus a.k.a. your memory epicenter.
Sleep deprived subjects with lower hippocampal activity
were then worse at retaining these memories.
I'm sorry, what are we talking about again?
I-- Sleep or puppies?
Alcohol, no.
Maybe we could just take a break for a couple of minutes.
(loud thump)
(loud slap)
(yells)
(books thump)
As you may notice, I'm a little bit irritated.
Science calls this an increase in negative mood states
a.k.a. I feel grumpy, tired, pissed,
and maybe even a little bit confused.
One study found that this general bad feeling
may be due to the dysregulation of connectivity
between the amygdala and the medial prefrontal cortex
after sleep loss.
This study suggests that after a normal rested state,
your prefrontal cortex has top-down control
over your emotional center: the amygdala.
So after sleep deprivation, the prefrontal cortex loses
its control over the brash pre-teen which is your amygdala.
Hence, making me a nightmare to work with.
Didn't you get that take? You didn't get it?
No, I don't want to do it again.
No, I think it did it perfectly.
Sleep deprivation not only makes me angry, but it also
convinces me that everyone else is mad at me.
One lab found that after sleep deprivation, subjects were
unable to discriminate between angry and friendly faces
and were more likely to read faces as threatening.
Would you please get that boom out of my face, Justin?
(throat clearing)
- Sorry.
- [Shannon] Are you mad at me?
(loud thump)
Forget about this.
You seem mad. You seem mad.
Aside from the messed up things sleep deprivation does
to your brain, missing a full night of sleep has some
major consequences for the rest of your body.
Sleep deprivation can cause an increase
in blood pressure and heart rate.
And those who are sleep deprived are at a higher-risk
for cardiovascular disease and coronary heart disease.
So while it may seem like a good idea to pull an all-nighter
studying for that final or trying to binge-watch a season
of 24 in real-time, prolonged sleep deprivation
is seriously detrimental to your health
and it's thought to eventually cause death.
Forbes Magazine thinks that it's costing America
400 billion dollars a year
and I can personally testify to the fact that
I'm mad and I've gotten nothing done on this paper.
On that note, I think it's time for me to check out.
Good night.
You guys can leave now.
Just turn the lights off when you go.
Bye.
(laughs)
That's how I feel.
(chimes)
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